Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18360640 | 0.85 | FAAH (0.40) | PRMT5WDR77FAAH | |
| SCHEMBL18360717 | 0.83 | MAPK1 (0.45) | MAPK1 | |
| SCHEMBL18360586 | 0.81 | PKM (0.37) | — | |
| SCHEMBL807471 | 0.79 | — | — | |
| SCHEMBL18360605 | 0.79 | MAPK1 (0.46) | MAPK1KDM4EALDH1A1 | |
| SCHEMBL18360685 | 0.74 | MAPK1 (0.44) | MAPK1 | |
| SCHEMBL18360718 | 0.74 | MAPK1 (0.40) | MAPK1 | |
| SCHEMBL18360662 | 0.72 | ALDH1A1 (0.35) | PRMT5WDR77KDM4EALDH1A1 | |
| SCHEMBL18360672 | 0.72 | — | — | |
| SCHEMBL18360686 | 0.71 | KMT2A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |