Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18399057 | 0.86 | LMNA (0.35) | LMNATDP1HRH4LRRK2PKM | |
| SCHEMBL23851488 | 0.74 | ALDH1A1 (0.48) | LMNATDP1HRH4SMN1; SMN2ALDH1A1 | |
| SCHEMBL30595880 | 0.74 | REN (0.44) | HRH4POLB | |
| SCHEMBL30422104 | 0.74 | CFTR (0.39) | — | |
| SCHEMBL23852693 | 0.72 | BPTF (0.46) | LMNAHRH4SMN1; SMN2ALDH1A1HSP90AA1 | |
| SCHEMBL18399115 | 0.72 | HRH4 (0.37) | LMNAHRH4SMN1; SMN2TSHRMAPT | |
| SCHEMBL23850969 | 0.71 | RXFP1 (0.39) | LMNAHRH4SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL30826926 | 0.70 | KDM4E (0.45) | TDP1TSHRPOLBKMT2A | |
| SCHEMBL25300556 | 0.69 | HTR3E (0.55) | LMNAHRH4SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL18399312 | 0.69 | REN (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |