Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | FGR | P09769 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | BLK | P51451 | 1/20 | 0.35 |
| ▸ | BMX | P51813 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18399006 | 0.89 | MKNK1 (0.46) | AXLMKNK1ROCK2CYP3A4L3MBTL1 | |
| SCHEMBL18399106 | 0.87 | TSHR (0.47) | — | |
| SCHEMBL18399071 | 0.78 | SMN1; SMN2 (0.48) | TRPV1L3MBTL1 | |
| SCHEMBL18399231 | 0.75 | CHEK1 (0.40) | LIMK1 | |
| SCHEMBL18399204 | 0.74 | TDP1 (0.45) | MKNK1ROCK2L3MBTL1 | |
| SCHEMBL25313919 | 0.73 | GABRP (0.40) | — | |
| SCHEMBL31721821 | 0.72 | ALDH1A1 (0.50) | AXLTRPV1ROCK2CYP3A4BTK | |
| SCHEMBL22750070 | 0.71 | ROCK2 (0.47) | ROCK2PDGFRBPDGFRA | |
| SCHEMBL25258769 | 0.70 | SMN1; SMN2 (0.52) | CYP3A4 | |
| SCHEMBL20617830 | 0.69 | AXL (0.67) | AXLMKNK1TRPV1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |