Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22873547 | 1.00 | GPR119 (0.40) | GPR119TRPV3RXRARXRBRXRG | |
| SCHEMBL28610193 | 1.00 | GPR119 (0.40) | GPR119TRPV3RXRARXRBRXRG | |
| SCHEMBL28610255 | 0.93 | LRRK2 (0.40) | GPR119RXRARXRBRXRGCCNK | |
| SCHEMBL18398983 | 0.93 | LRRK2 (0.40) | GPR119RXRARXRBRXRGCCNK | |
| SCHEMBL20437352 | 0.93 | LRRK2 (0.40) | GPR119RXRARXRBRXRGCCNK | |
| SCHEMBL31084394 | 0.92 | GPR119 (0.39) | GPR119RXRARXRBRXRGCCNK | |
| SCHEMBL18399288 | 0.92 | TRPV3 (0.41) | GPR119TRPV3RXRARXRBRXRG | |
| SCHEMBL21796877 | 0.92 | TRPV3 (0.41) | GPR119TRPV3RXRARXRBRXRG | |
| SCHEMBL28608598 | 0.92 | TRPV3 (0.41) | GPR119TRPV3RXRARXRBRXRG | |
| SCHEMBL21796835 | 0.87 | RXRA (0.45) | GPR119RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3325449-A1 | COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-05-30 | — | — | EP | disclosed |
| WO-2017012576-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-26 | — | — | WO | disclosed |