Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964598 | 0.87 | GABRA1 (0.50) | GABRA1GABRB2ALDH1A1KDM4EMEN1 | |
| SCHEMBL952797 | 0.82 | ESR1 (0.36) | GABRA1GABRB2ALDH1A1KDM4EHPGD | |
| SCHEMBL29459661 | 0.77 | ERN1 (0.50) | KDM4ETRIM24TRIM33ERN1CYP3A4 | |
| SCHEMBL1002739 | 0.77 | ERN1 (0.50) | KDM4ETRIM24TRIM33ERN1CYP3A4 | |
| SCHEMBL12775744 | 0.76 | MEN1 (0.42) | ALDH1A1KDM4EMEN1LMNAHPGD | |
| SCHEMBL1527075 | 0.75 | GABRA1 (0.52) | GABRA1GABRB2TRIM24TRIM33ERN1 | |
| SCHEMBL29951885 | 0.75 | GABRA1 (0.52) | GABRA1GABRB2TRIM24TRIM33ERN1 | |
| SCHEMBL2475390 | 0.75 | GABRA1 (0.56) | GABRA1GABRB2PRKCIESR1ESR2 | |
| SCHEMBL29719025 | 0.75 | GABRA1 (0.56) | GABRA1GABRB2PRKCIESR1ESR2 | |
| SCHEMBL4650198 | 0.74 | CYP3A4 (0.44) | ALDH1A1KDM4ELMNAERN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984324-B1 | MANDELIC HYDRAZIDES | MERCK PATENT GMBH (DE) | 2011-05-18 | — | — | EP | disclosed |
| US-7776920-B2 | Mandelic hydrazides | MERCK PATENT GMBH (DE) | 2010-08-17 | — | — | US | disclosed |
| US-20090221712-A1 | MANDELIC HYDRAZIDES | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1984324-A1 | MANDELIC HYDRAZIDES | Merck Patent GmbH (DE) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007093264-A1 | MANDELIC HYDRAZIDES | MERCK PATENT GMBH (DE) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221712-A1 | MANDELIC HYDRAZIDES | HK1, GLS, AGK | GABRA1 3922/4885GABRB2 4662/4885ALDH1A1 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.