SCHEMBL18407477

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL17914538	0.88	PDE2A (0.44)	OPRL1PDE2ACHRNB2CHRNA4
	SCHEMBL15577422	0.87	RPS6KA3 (0.38)	OPRL1MAOARPS6KA3PDE2ACHRNB2
	SCHEMBL24664746	0.85	PDE2A (0.40)	OPRL1PDE2ACHRNB2CHRNA4
	SCHEMBL13499048	0.85	APP (0.41)	OPRL1PDE2ACHRNB2CHRNA4
	SCHEMBL25693956	0.83	CHRNB2 (0.37)	PDE2ACHRNB2CHRNA4GAA
	SCHEMBL16285922	0.83	APP (0.43)	OPRL1PDE2ACHRNB2CHRNA4
	SCHEMBL22502744	0.82	PDE2A (0.41)	OPRL1PDE2ACHRNB2CHRNA4
	SCHEMBL15785387	0.81	HTR6 (0.45)	PDE2ACHRNB2CHRNA4TLR9TLR8
	SCHEMBL19245044	0.81	CHRNB2 (0.35)	OPRL1CHRNB2CHRNA4KIF11GAA
	SCHEMBL11977022	0.79	TLR9 (0.44)	OPRL1PDE2ACHRNB2CHRNA4TLR9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.