Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | TYK2 | P29597 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18409291 | 0.81 | JAK2 (0.37) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18409113 | 0.81 | ALDH1A1 (0.36) | — | |
| SCHEMBL18409258 | 0.81 | S1PR1 (0.38) | NR1H4S1PR1S1PR5 | |
| SCHEMBL18409164 | 0.80 | JAK2 (0.42) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18409281 | 0.80 | JAK2 (0.39) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18409102 | 0.79 | LMNA (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18409110 | 0.77 | POLB (0.33) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18409321 | 0.77 | JAK2 (0.38) | JAK2JAK1TYK2JAK3NR1H4 | |
| SCHEMBL18409541 | 0.76 | PIK3CA (0.35) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL18409180 | 0.76 | TYK2 (0.35) | JAK2JAK1TYK2JAK3NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017012647-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2017-01-26 | — | — | WO | disclosed |