Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 8/20 | 0.52 |
| ▸ | GSK3B | P49841 | 8/20 | 0.52 |
| ▸ | SRPK1 | Q96SB4 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.52 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 11/20 | 0.49 |
| ▸ | HIPK4 | Q8NE63 | 5/20 | 0.49 |
| ▸ | STK3 | Q13188 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | CDK8 | P49336 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.49 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068186 | 0.86 | XIAP (0.49) | CLK4ACVR1HIPK4STK3AURKB | |
| SCHEMBL30863254 | 0.82 | GSK3A (0.46) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL13170010 | 0.82 | KDM4E (0.56) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL2635287 | 0.80 | TAS2R14 (0.57) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL5031654 | 0.79 | P2RX7 (0.53) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL29640129 | 0.79 | P2RX7 (0.53) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL1464316 | 0.78 | GSK3A (0.49) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL18425134 | 0.78 | ACVR1 (0.49) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL16359172 | 0.77 | GSK3A (0.44) | GSK3AGSK3BSRPK1AURKAPRKX | |
| SCHEMBL1464329 | 0.77 | CLK4 (0.45) | GSK3AGSK3BSRPK1AURKAPRKX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207267-A1 | (R)-Glutarimide CRBN Ligands and Methods of Use | BEIGENE SWITZERLAND GMBH (CH) | 2024-06-27 | — | — | US | disclosed |
| US-20240207267-A1 | (R)-Glutarimide CRBN Ligands and Methods of Use | BEIGENE SWITZERLAND GMBH (CH) | 2024-06-27 | — | — | US | disclosed |
| WO-2022268052-A9 | (R) -GLUTARIMIDE CRBN LIGANDS AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-08-17 | — | — | WO | disclosed |
| US-20230033285-A1 | Protease Inhibitors for Treatment of Coronavirus Infections | THE SCRIPPS RESEARCH INSTITUTE | 2023-02-02 | — | — | US | disclosed |
| WO-2022268052-A1 | (R) -GLUTARIMIDE CRBN LIGANDS AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-12-29 | — | — | WO | disclosed |
| WO-2022143856-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-07-07 | — | — | WO | disclosed |
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240207267-A1 | (R)-Glutarimide CRBN Ligands and Methods of Use | CRBN, CDR2, CRKL | GSK3A 1434/4885GSK3B 1160/4885SRPK1 2482/4885 |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | GSK3A 3463/4885GSK3B 3245/4885SRPK1 4082/4885 |
| US-20230033285-A1 | Protease Inhibitors for Treatment of Coronavirus Infections | ACE, ACE2, TMPRSS2 | GSK3A 3752/4885GSK3B 2894/4885SRPK1 2705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.