Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | DHPS | P49366 | 8/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1809226 | 0.90 | PDGFRB (0.48) | PDGFRBPDGFRADHPSFYNRELA | |
| SCHEMBL1812558 | 0.90 | PDGFRB (0.48) | PDGFRBPDGFRADHPSTRPM8FYN | |
| SCHEMBL1817177 | 0.83 | DHPS (0.57) | PDGFRBPDGFRADHPSFYN | |
| SCHEMBL12958859 | 0.81 | TRPM8 (0.42) | TRPM8ESR2ABCG2 | |
| SCHEMBL28584109 | 0.78 | DHPS (0.65) | PDGFRBPDGFRADHPSABCG2 | |
| SCHEMBL12958862 | 0.76 | LMNA (0.43) | PDGFRBPDGFRAABCG2 | |
| SCHEMBL12958858 | 0.76 | ESR2 (0.47) | TRPM8ESR2ABCG2 | |
| SCHEMBL375243 | 0.75 | LMNA (0.46) | PDGFRBPDGFRAESR2 | |
| SCHEMBL30410753 | 0.74 | DHPS (0.79) | DHPS | |
| SCHEMBL28568909 | 0.74 | DHPS (0.79) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |