Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436557 | 0.84 | ADRB1 (0.43) | PRKDCMAPK1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL31276657 | 0.82 | AKR1C3 (0.41) | PRKDCSYKMAPK1ALDH1A1ALOX15 | |
| SCHEMBL20448572 | 0.82 | PRKDC (0.38) | LMNAPRKDCSYKMAPK1ALDH1A1 | |
| SCHEMBL6624674 | 0.82 | MAPT (0.46) | LMNAPRKDCMAPK1ALDH1A1FFAR2 | |
| SCHEMBL24352269 | 0.80 | ALDH1A1 (0.46) | LMNAPRKDCMAPK1ALDH1A1ALOX15 | |
| SCHEMBL9975646 | 0.80 | LMNA (0.46) | LMNACYP2C19MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL19012685 | 0.80 | MAPT (0.45) | LMNAPRKDCSYKMAPK1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28025290 | 0.79 | KEAP1 (0.53) | SYKCHRNA7CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL21396334 | 0.78 | BACE1 (0.37) | PRKDCSYKMAPK1ALDH1A1FFAR2 | |
| SCHEMBL27621709 | 0.78 | CYP2C19 (0.47) | LMNACYP2C19MAPK1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |
| CN-87106925-A | Naphthyridine and quinoline-carboxylic acid antibacterial agents that the 1-tertiary alkyl replaces | — | 1988-09-14 | — | — | CN | disclosed |