Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 15/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19012515 | 0.91 | SLC6A9 (0.50) | MEN1TSHRHTTKMT2ASLC6A9 | |
| SCHEMBL19012519 | 0.89 | SLC6A9 (0.53) | MEN1TSHRHTTKMT2ASLC6A9 | |
| SCHEMBL22055741 | 0.84 | POLB (0.57) | MEN1TSHRHTTKMT2ASLC6A9 | |
| SCHEMBL27603987 | 0.83 | KMT2A (0.50) | MEN1TSHRHTTKMT2A | |
| SCHEMBL18436327 | 0.83 | CTSB (0.51) | MEN1TSHRHTTKMT2A | |
| SCHEMBL27873105 | 0.82 | KMT2A (0.49) | MEN1TSHRHTTKMT2A | |
| SCHEMBL12964250 | 0.77 | RIPK1 (0.64) | MEN1TSHRHTTKMT2A | |
| SCHEMBL2707267 | 0.76 | SIGMAR1 (0.61) | NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL27412469 | 0.75 | RIPK1 (0.62) | MEN1TSHRHTTKMT2A | |
| SCHEMBL27831765 | 0.75 | RIPK1 (0.58) | MEN1TSHRHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3124482-B1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN) | 2019-09-11 | — | — | EP | disclosed |
| EP-3124482-A1 | QUINOLINE DERIVATIVES AS SMO INHIBITORS | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2017-02-01 | — | — | EP | disclosed |