Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9110123 | 0.77 | MAOA (0.57) | FLT3MAOAMAOBLRRK2PDGFRA | |
| SCHEMBL5703588 | 0.76 | LRRK2 (0.65) | MAOAMAOBLRRK2PDGFRAFER | |
| SCHEMBL135332 | 0.74 | GSK3B (0.56) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL29032840 | 0.73 | GSK3B (0.54) | LRRK2PDGFRAFERLTKCDK8 | |
| Ammonia Solution, Strong SCHEMBL28821133 | 0.73 | GSK3B (0.54) | LRRK2PDGFRAFERLTKCDK8 | |
| SCHEMBL9353414 | 0.71 | LRRK2 (0.47) | FLT3MAOAMAOBLRRK2PDGFRA | |
| SCHEMBL29589906 | 0.70 | HDAC4 (0.41) | FLT3LMNAMAPTPARP10PARP11 | |
| SCHEMBL3671263 | 0.70 | HNF4A (0.42) | FLT3LMNAMAPTPARP10PARP11 | |
| SCHEMBL52297 | 0.70 | HDAC4 (0.41) | FLT3LMNAMAPTPARP10PARP11 | |
| SCHEMBL5616554 | 0.68 | GSK3B (0.52) | LRRK2PDGFRAFERLTKCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3575288-A1 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-12-04 | — | — | EP | disclosed |
| EP-3124475-A1 | QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-02-01 | — | — | EP | disclosed |