SCHEMBL18447372

SCHEMBL18447372

CC(C)(C)OC(=O)N1CC(c2ccc(F)c(F)c2)N(C(=O)Nc2cccc(F)c2F)C1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 1/20 0.37
HDAC1 Q13547 2/20 0.35
HDAC2 Q92769 2/20 0.35
SCN9A Q15858 3/20 0.35
ITGB3 P05106 1/20 0.34
ITGB1 P05556 1/20 0.34
ITGAV P06756 1/20 0.34
ITGA5 P08648 1/20 0.34
ITGA4 P13612 1/20 0.34
SCN5A Q14524 1/20 0.34
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
TAS1R2 Q8TE23 1/20 0.33
TP53 P04637 1/20 0.33
GPR119 Q8TDV5 1/20 0.33
KDM4E B2RXH2 1/20 0.33
NTRK1 P04629 4/20 0.33
NAMPT P43490 2/20 0.32
PREP P48147 1/20 0.32
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29662048 1.00 USP30 (0.37) USP30HDAC1HDAC2SCN9AITGB3
SCHEMBL29662057 0.90 MEN1 (0.39) USP30HDAC1HDAC2SCN9AITGB3
SCHEMBL28773807 0.90 MEN1 (0.39) USP30HDAC1HDAC2SCN9AITGB3
SCHEMBL18446673 0.90 MEN1 (0.39) USP30HDAC1HDAC2SCN9AITGB3
SCHEMBL23111133 0.74 TAS1R3 (0.39) HDAC1HDAC2ITGB3ITGB1ITGAV
SCHEMBL18447603 0.74 TAS1R3 (0.39) HDAC1HDAC2ITGB3ITGB1ITGAV
SCHEMBL29662055 0.74 TAS1R3 (0.39) HDAC1HDAC2ITGB3ITGB1ITGAV
SCHEMBL28860321 0.73 KDM4E (0.40) ITGB3ITGB1ITGAVITGA5ITGA4
SCHEMBL23111135 0.68 KDM4E (0.39) ITGB3ITGB1ITGAVITGA5ITGA4
SCHEMBL18447237 0.67 ADAMTS5 (0.39) USP30GPR119KDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108137512-B Cyclic N-amide compounds useful as herbicides FMC公司 2022-05-31 CN disclosed
US-11178873-B2 Cyclic N-carboxamide compounds useful as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
EP-3328836-B1 CYCLIC N-CARBOXAMIDE COMPOUNDS USEFUL AS HERBICIDES FMC CORP (US) 2021-03-24 EP disclosed
US-10653148-B2 2020-05-19 US disclosed
US-20180213788-A1 CYCLIC N-CARBOXAMIDE COMPOUNDS USEFUL AS HERBICIDES FMC CORPORATION 2018-08-02 US disclosed
EP-3328836-A1 CYCLIC N-CARBOXAMIDE COMPOUNDS USEFUL AS HERBICIDES E. I. du Pont de Nemours and Company (US) 2018-06-06 EP disclosed
WO-2017023515-A1 CYCLIC N-CARBOXAMIDE COMPOUNDS USEFUL AS HERBICIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2017-02-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10653148-B2 CYP1B1, CYP1A1, C5 USP30 4805/4885HDAC1 3316/4885HDAC2 3353/4885
US-11178873-B2 Cyclic N-carboxamide compounds useful as herbicides CHRM2, NIT2, CHRM1 USP30 4069/4885HDAC1 545/4885HDAC2 452/4885
US-20180213788-A1 CYCLIC N-CARBOXAMIDE COMPOUNDS USEFUL AS HERBICIDES CHRM2, NIT2, CHRM1 USP30 4069/4885HDAC1 545/4885HDAC2 452/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.