Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18697222 | 0.80 | KLKB1 (0.38) | KLKB1MAP4K1 | |
| SCHEMBL18697152 | 0.77 | HPGDS (0.33) | KLKB1 | |
| SCHEMBL12470838 | 0.76 | MAPT (0.54) | METAKR1C3KLKB1MAP4K1TNIK | |
| SCHEMBL27948373 | 0.72 | MET (0.51) | METAKR1C3KLKB1MAP4K1TNIK | |
| SCHEMBL18371396 | 0.69 | KLKB1 (0.67) | METAKR1C3KLKB1MAP4K1TNIK | |
| SCHEMBL4215471 | 0.68 | KMO (0.55) | METAKR1C3FGFR2FGFR3PDE3B | |
| SCHEMBL28816284 | 0.67 | TNIK (0.61) | METAKR1C3TNIKFGFR2FGFR3 | |
| SCHEMBL14783511 | 0.67 | AKR1C3 (0.54) | METAKR1C3TNIKFGFR2FGFR3 | |
| SCHEMBL17460814 | 0.67 | TNIK (0.53) | METAKR1C3TNIKFGFR2FGFR3 | |
| SCHEMBL18371384 | 0.66 | KLKB1 (0.65) | METKLKB1MAP4K1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023557-B2 | Therapeutic inhibitory compounds | LIFESCI PHARMACEUTICALS, INC. (BB) | 2018-07-17 | — | — | US | disclosed |
| US-20170029406-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | ATTUNE PHARMACEUTICALS, INC. | 2017-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029406-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | KLKB1, SERPINB1, SERPINE1 | MET 4844/4885AKR1C3 161/4885KLKB1 1/4885 |
| US-10023557-B2 | Therapeutic inhibitory compounds | KLKB1, SERPINB1, SERPINE1 | MET 4844/4885AKR1C3 161/4885KLKB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.