Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.70 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.70 |
| ▸ | TERT | O14746 | 8/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.57 |
| ▸ | TUBB | P07437 | 1/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.57 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12556208 | 0.88 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL6612282 | 0.86 | TUBB4A (0.76) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL16704751 | 0.85 | CYP1A1 (0.76) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL21647169 | 0.85 | CYP1A2 (0.73) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL27381836 | 0.85 | CYP1A2 (0.73) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL4649487 | 0.84 | CYP3A4 (0.76) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL29612043 | 0.84 | TERT (0.77) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL988001 | 0.84 | TERT (0.77) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL14286203 | 0.82 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 | |
| SCHEMBL6613755 | 0.81 | TERT (0.77) | CYP1A2CYP3A4CYP2C19NCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9895344-B2 | Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof | EMORY UNIVERSITY (US) | 2018-02-20 | — | — | US | disclosed |
| US-9895344-B2 | Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof | EMORY UNIVERSITY (US) | 2018-02-20 | — | — | US | disclosed |
| US-9504674-B2 | TrkB agonists and methods of use | EMORY UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150174107-A1 | TRKB AGONISTS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| US-20110144196-A1 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | EMORY UNIVERSITY (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110144196-A1 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | EMORY UNIVERSITY (US) | 2011-06-16 | — | — | US | disclosed |
| EP-2323649-A2 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | Emory University (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010011836-A2 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | EMORY UNIVERSITY (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150174107-A1 | TRKB AGONISTS AND METHODS OF USE | NTRK2, BDNF, NTRK1 | CYP1A2 775/4885CYP3A4 1323/4885CYP2C19 1376/4885 |
| US-20110144196-A1 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | NTRK2, BDNF, HTR7 | CYP1A2 703/4885CYP3A4 1397/4885CYP2C19 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.