Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23870296 | 0.79 | KCNH2 (0.38) | KDM4EL3MBTL1FFAR1FFAR4ACACB | |
| SCHEMBL12463337 | 0.78 | KDM4E (0.40) | KDM4EL3MBTL1FFAR1FFAR4NPC1 | |
| SCHEMBL1535553 | 0.78 | GRM5 (0.50) | RAB9AACACBALDH1A1GRM5MELK | |
| SCHEMBL10162239 | 0.77 | L3MBTL1 (0.42) | KDM4EL3MBTL1FFAR1FFAR4NPC1 | |
| SCHEMBL9494958 | 0.76 | ACACB (0.49) | FFAR1FFAR4ACACBGRM5CYP2A6 | |
| SCHEMBL22031550 | 0.74 | GRM5 (0.46) | FFAR1FFAR4ACACBALDH1A1GRM5 | |
| SCHEMBL31044575 | 0.74 | GRM5 (0.46) | FFAR1FFAR4ACACBALDH1A1GRM5 | |
| SCHEMBL4521816 | 0.74 | ALDH1A1 (0.37) | KDM4EFFAR1FFAR4NPC1RAB9A | |
| SCHEMBL21183985 | 0.74 | ALDH1A1 (0.34) | ALDH1A1GRM5MELK | |
| SCHEMBL14946755 | 0.74 | ALDH1A1 (0.39) | SMN1; SMN2ACACBALDH1A1GRM5MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170037039-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037039-A1 | RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF | RXRA, RARB, RARA | KDM4E 4119/4885L3MBTL1 1949/4885FFAR1 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.