Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1976213 | 0.99 | CTSV (0.51) | CTSVCTSLADORA2AADORA1ERCC1 | |
| SCHEMBL312031 | 0.88 | TERT (0.49) | ADORA2AMEN1KMT2AKDM4EHPGD | |
| SCHEMBL1849234 | 0.85 | HPGD (0.53) | CTSVCTSLADORA2AADORA1MEN1 | |
| Bromide SCHEMBL1978677 | 0.84 | HPGD (0.51) | CTSVCTSLADORA2AADORA1MEN1 | |
| SCHEMBL12588956 | 0.82 | ALDH1A1 (0.57) | MEN1KMT2AKDM4EHPGDLMNA | |
| SCHEMBL12588953 | 0.82 | QPCT (0.43) | ADORA2AADORA1MEN1KMT2AKDM4E | |
| SCHEMBL340804 | 0.77 | CTSV (0.52) | CTSVCTSLADORA2AADORA1ERCC1 | |
| SCHEMBL311330 | 0.73 | KMT2A (0.43) | CTSVCTSLADORA2AADORA1MEN1 | |
| SCHEMBL313903 | 0.72 | ALDH1A1 (0.68) | CTSVCTSLADORA2AADORA1MEN1 | |
| SCHEMBL14702307 | 0.72 | CYP1A1 (0.55) | CTSVCTSLADORA2AADORA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9895344-B2 | Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof | EMORY UNIVERSITY (US) | 2018-02-20 | — | — | US | disclosed |
| US-9895344-B2 | Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof | EMORY UNIVERSITY (US) | 2018-02-20 | — | — | US | disclosed |
| EP-2579870-B1 | TRKB AGONISTS AND METHODS OF USE | UNIV EMORY (US) | 2018-02-14 | — | — | EP | disclosed |
| EP-2579870-B1 | TRKB AGONISTS AND METHODS OF USE | UNIV EMORY (US) | 2018-02-14 | — | — | EP | disclosed |
| US-9504674-B2 | TrkB agonists and methods of use | EMORY UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-9504674-B2 | TrkB agonists and methods of use | EMORY UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-9504674-B2 | TrkB agonists and methods of use | EMORY UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| CN-102143744-B | Application of 7, 8-dihydroxyflavone and derivatives thereof in preparing medicament for treating depression | 爱默蕾大学 | 2016-08-31 | — | — | CN | disclosed |
| CN-105832717-A | Treatment of various disorders with 7,8-dihydroxyflavone and derivatives thereof | 爱默蕾大学 | 2016-08-10 | — | — | CN | disclosed |
| US-20150174107-A1 | TRKB AGONISTS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| US-20130040947-A1 | TRKB AGONISTS AND METHODS OF USE | EMORY UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040947-A1 | TRKB AGONISTS AND METHODS OF USE | EMORY UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040947-A1 | TRKB AGONISTS AND METHODS OF USE | EMORY UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2011156479-A9 | TRKB AGONISTS AND METHODS OF USE | EMORY UNIVERSITY (US) | 2012-05-31 | — | — | WO | disclosed |
| WO-2011156479-A2 | TRKB AGONISTS AND METHODS OF USE | EMORY UNIVERSITY (US) | 2011-12-15 | — | — | WO | disclosed |
| US-20110144196-A1 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | EMORY UNIVERSITY (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110144196-A1 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | EMORY UNIVERSITY (US) | 2011-06-16 | — | — | US | disclosed |
| EP-2323649-A2 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | Emory University (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010011836-A2 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | EMORY UNIVERSITY (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010011836-A2 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | EMORY UNIVERSITY (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040947-A1 | TRKB AGONISTS AND METHODS OF USE | NTRK2, BDNF, NTRK1 | CTSV 1920/4885CTSL 2757/4885ADORA2A 362/4885 |
| US-20150174107-A1 | TRKB AGONISTS AND METHODS OF USE | NTRK2, BDNF, NTRK1 | CTSV 1914/4885CTSL 2777/4885ADORA2A 339/4885 |
| US-20110144196-A1 | TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF | NTRK2, BDNF, HTR7 | CTSV 2863/4885CTSL 3333/4885ADORA2A 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.