Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22692965 | 0.77 | FAAH (0.40) | ATMPRSS1PRSS2PRSS3LMNA | |
| SCHEMBL22363336 | 0.75 | FAAH (0.39) | ATMPRSS1PRSS2PRSS3LMNA | |
| SCHEMBL675017 | 0.75 | MMP9 (0.56) | MMP9MMP8MMP13MEN1LMNA | |
| SCHEMBL9395046 | 0.75 | MMP9 (0.56) | MMP9MMP8MMP13MEN1LMNA | |
| SCHEMBL18248622 | 0.74 | CYP2C19 (0.45) | MMP9MMP8MMP13MEN1LMNA | |
| SCHEMBL18248588 | 0.74 | CYP2C19 (0.45) | MMP9MMP8MMP13MEN1LMNA | |
| SCHEMBL4938951 | 0.72 | CYP2C19 (0.46) | MMP9MMP8MMP13MEN1LMNA | |
| SCHEMBL30437687 | 0.72 | NR1I2 (0.39) | ATMPRSS1PRSS2PRSS3LMNA | |
| SCHEMBL18248573 | 0.72 | MMP9 (0.47) | MMP9MMP8MMP13LMNACYP3A4 | |
| SCHEMBL5470596 | 0.71 | LMNA (0.40) | MMP9MMP8MMP13LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |