Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25671080 | 0.78 | TDP1 (0.40) | POLBTDP1 | |
| SCHEMBL25671162 | 0.78 | TDP1 (0.40) | POLBTDP1 | |
| SCHEMBL22995685 | 0.77 | MAPK1 (0.38) | MAPK1LMNA | |
| SCHEMBL25671082 | 0.77 | TDP1 (0.36) | TDP1 | |
| SCHEMBL18501606 | 0.77 | TDP1 (0.36) | TDP1 | |
| SCHEMBL17471306 | 0.73 | MAPK1 (0.52) | MAPK1 | |
| SCHEMBL21104000 | 0.72 | CAPN1 (0.33) | TDP1 | |
| SCHEMBL21103841 | 0.70 | ALDH1A1 (0.37) | POLBTDP1 | |
| SCHEMBL21089991 | 0.69 | POLB (0.31) | POLB | |
| SCHEMBL22373733 | 0.69 | HRH4 (0.34) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753638-B2 | Conjugated oligonucleotides | UNIVERSITY OF MASSACHUSETTS (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753638-B2 | Conjugated oligonucleotides | UNIVERSITY OF MASSACHUSETTS (US) | 2023-09-12 | — | — | US | disclosed |
| US-20200339983-A1 | BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY | UNIVERSITY OF MASSACHUSETTS | 2020-10-29 | — | — | US | disclosed |
| US-20190185855-A1 | CONJUGATED OLIGONUCLEOTIDES | UNIVERSITY OF MASSACHUSETTS | 2019-06-20 | — | — | US | disclosed |
| US-20170043024-A1 | BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY | UNIVERSITY OF MASSACHUSETTS | 2017-02-16 | — | — | US | disclosed |
| US-20170043024-A1 | BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY | UNIVERSITY OF MASSACHUSETTS | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753638-B2 | Conjugated oligonucleotides | DCLRE1B, DCLRE1A, TNNC1 | MAPK1 4848/4885LMNA 3065/4885POLB 32/4885 |
| US-20200339983-A1 | BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY | DCLRE1B, RTCB, RNASE1 | MAPK1 4396/4885LMNA 1428/4885POLB 440/4885 |
| US-20170043024-A1 | BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY | DCLRE1B, RTCB, RNASE1 | MAPK1 4396/4885LMNA 1428/4885POLB 440/4885 |
| US-20190185855-A1 | CONJUGATED OLIGONUCLEOTIDES | DCLRE1B, DCLRE1A, TNNC1 | MAPK1 4848/4885LMNA 3065/4885POLB 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.