Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17082787 | 0.84 | CHRNB2 (0.41) | ALDH1A1POLBMAP4K4 | |
| SCHEMBL15285349 | 0.80 | KDM4E (0.35) | POLB | |
| SCHEMBL19009037 | 0.79 | ALDH1A1 (0.34) | ALDH1A1MAP4K4MCL1LMNA | |
| SCHEMBL21097919 | 0.78 | DGAT1 (0.33) | — | |
| SCHEMBL4726144 | 0.77 | KMT2A (0.52) | ALDH1A1LMNA | |
| SCHEMBL23298052 | 0.77 | CHRNB2 (0.31) | — | |
| SCHEMBL14407039 | 0.76 | SLC6A12 (0.40) | ALDH1A1POLB | |
| SCHEMBL15285886 | 0.76 | BRD4 (0.50) | POLB | |
| SCHEMBL19151669 | 0.75 | NR1H2 (0.53) | ALDH1A1 | |
| SCHEMBL31348959 | 0.75 | ARG1 (0.33) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027684-A1 | FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. (US) | 2017-02-16 | — | — | WO | disclosed |