Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13132303 | 0.84 | PTGER4 (0.41) | SCN9AALDH1A1HTTCYP2A6 | |
| SCHEMBL18508729 | 0.81 | SCN5A (0.46) | SCN5ASCN9AALDH1A1HTTKMO | |
| SCHEMBL18509097 | 0.68 | SCN5A (0.33) | SCN5ASCN9A | |
| SCHEMBL14931778 | 0.67 | HCAR3 (0.48) | CYP2A6 | |
| SCHEMBL28135788 | 0.67 | KMO (0.44) | CYP2A6KMO | |
| SCHEMBL2806227 | 0.66 | PKM (0.41) | ALDH1A1HTT | |
| SCHEMBL4249553 | 0.66 | REN (0.45) | ALDH1A1CYP2A6KMO | |
| SCHEMBL13448582 | 0.66 | SCN5A (0.31) | SCN5ASCN9A | |
| SCHEMBL13132262 | 0.66 | PTGER4 (0.44) | SCN9AALDH1A1HTTCYP2A6 | |
| SCHEMBL28473872 | 0.63 | HCAR3 (0.49) | CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |