Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372297 | 1.00 | NAMPT (0.53) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| SCHEMBL379486 | 1.00 | NAMPT (0.53) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5087159 | 0.99 | NAMPT (0.52) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| Bromide SCHEMBL11455325 | 0.99 | NAMPT (0.52) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| Hydrochloric Acid SCHEMBL20214289 | 0.99 | NAMPT (0.52) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| SCHEMBL4953664 | 0.96 | NAMPT (0.49) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| SCHEMBL4953654 | 0.96 | NAMPT (0.49) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| SCHEMBL5172065 | 0.89 | F2 (0.51) | NAMPTLMNAMMP2MMP9ALDH1A1 | |
| Glycyl Proline SCHEMBL28466633 | 0.86 | F2 (0.48) | LMNAMMP2MMP9ALDH1A1EPHX2 | |
| SCHEMBL28579566 | 0.86 | LMNA (0.48) | LMNAMMP2MMP9ALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239860-A1 | THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | UNIV PENNSYLVANIA (US) | 2024-07-18 | — | — | US | disclosed |
| US-20210198338-A1 | THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | UNIV PENNSYLVANIA (US) | 2021-07-01 | — | — | US | disclosed |
| US-10189884-B2 | Thioamide-modified peptides and uses thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2019-01-29 | — | — | US | disclosed |
| US-20170044231-A1 | NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | UNIV PENNSYLVANIA (US) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239860-A1 | THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | PTMS, LNPEP, IAPP | NAMPT 305/4885LMNA 4311/4885MMP2 3424/4885 |
| US-10189884-B2 | Thioamide-modified peptides and uses thereof | PTMS, LNPEP, IAPP | NAMPT 305/4885LMNA 4311/4885MMP2 3424/4885 |
| US-20170044231-A1 | NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | PTMS, IAPP, LNPEP | NAMPT 313/4885LMNA 4440/4885MMP2 3753/4885 |
| US-20210198338-A1 | THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF | PTMS, LNPEP, IAPP | NAMPT 305/4885LMNA 4311/4885MMP2 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.