Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glycyl Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | HPN | P05981 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172065 | 0.96 | F2 (0.51) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL28579566 | 0.93 | LMNA (0.48) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| Glycyl Proline SCHEMBL28393314 | 0.88 | CA2 (0.41) | ALDH1A1CA1CA2 | |
| SCHEMBL4372297 | 0.86 | NAMPT (0.53) | ALDH1A1MAPK1MMP2MMP9EPHX2 | |
| SCHEMBL379486 | 0.86 | NAMPT (0.53) | ALDH1A1MAPK1MMP2MMP9EPHX2 | |
| SCHEMBL18509855 | 0.86 | NAMPT (0.53) | ALDH1A1MAPK1MMP2MMP9EPHX2 | |
| Hydrochloric Acid SCHEMBL20214289 | 0.85 | NAMPT (0.52) | ALDH1A1MAPK1MMP2MMP9EPHX2 | |
| Bromide SCHEMBL11455325 | 0.85 | NAMPT (0.52) | ALDH1A1MAPK1MMP2MMP9EPHX2 | |
| Hydrochloric Acid SCHEMBL5087159 | 0.85 | NAMPT (0.52) | ALDH1A1MAPK1MMP2MMP9EPHX2 | |
| SCHEMBL4953654 | 0.82 | NAMPT (0.49) | ALDH1A1MAPK1MMP2MMP9EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111500672-B | Glycylproline dipeptide aminopeptidase determination kit with high analysis sensitivity and preparation method and application thereof | 中科梅奥(山东)医学检验有限公司 | 2021-08-24 | — | — | CN | disclosed |
| CN-111500672-A | Glycylproline dipeptide aminopeptidase determination kit with high analysis sensitivity and preparation method and application thereof | 中科梅奥(山东)医学检验有限公司 | 2020-08-07 | — | — | CN | disclosed |