Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1851052 | 0.91 | GPR52 (0.58) | GPR52KMT2ADGAT2MAPTKDM4E | |
| SCHEMBL1853932 | 0.89 | GPR52 (0.63) | GPR52KMT2AMAPTKDM4EKLKB1 | |
| SCHEMBL3217594 | 0.88 | GPR52 (0.75) | GPR52PTGER4ADORA3ADORA2B | |
| SCHEMBL1849604 | 0.87 | GPR52 (0.81) | GPR52CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1850671 | 0.86 | GPR52 (0.62) | GPR52KMT2ADGAT2KLKB1PTGER4 | |
| SCHEMBL1849364 | 0.86 | GPR52 (0.51) | GPR52ALDH1A1 | |
| SCHEMBL1850719 | 0.85 | GPR52 (0.61) | GPR52DGAT2MAPTPTGER4ADORA3 | |
| SCHEMBL1852548 | 0.85 | GPR52 (0.70) | GPR52PTGER4ADORA3ADORA2B | |
| SCHEMBL1848805 | 0.82 | GPR52 (0.53) | GPR52KMT2AMAPTKDM4EKLKB1 | |
| SCHEMBL1850248 | 0.81 | GPR52 (0.54) | GPR52PTGER4ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323978-A1 | AMIDE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010018874-A1 | AMIDE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |