Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 4/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 4/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 4/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10232843 | 0.84 | HRH3 (0.39) | GABRA5GABRB2SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL17190309 | 0.83 | ALDH1A1 (0.32) | KCNH2HRH3ALDH1A1TDP1 | |
| SCHEMBL29108912 | 0.81 | CCR2 (0.40) | KCNH2 | |
| SCHEMBL16768020 | 0.81 | CCR2 (0.40) | KCNH2 | |
| SCHEMBL1261174 | 0.79 | HRH3 (0.44) | GABRA5GABRB2SLC6A12SLC6A11SLC6A13 | |
| Hydrochloric Acid SCHEMBL2942000 | 0.78 | HRH3 (0.43) | GABRA5GABRB2SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL25872174 | 0.78 | BRD4 (0.49) | MAPTMEN1KMT2ATSHR | |
| SCHEMBL16249765 | 0.77 | ALDH1A1 (0.32) | MAPTALDH1A1POLBTDP1 | |
| SCHEMBL3421354 | 0.77 | — | — | |
| SCHEMBL18705049 | 0.76 | CHRM5 (0.39) | MEN1KMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159504-A1 | 7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) | VERTEX PHARMACEUTICALS INCORPORATED | 2023-05-25 | — | — | US | disclosed |
| US-10018624-B1 | Azetidine-substituted fluorescent compounds | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2018-07-10 | — | — | US | disclosed |
| US-20180172677-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | HOWARD HUGHES MEDICAL INSTITUTE | 2018-06-21 | — | — | US | disclosed |
| US-9933417-B2 | Azetidine-substituted fluorescent compounds | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2018-04-03 | — | — | US | disclosed |
| US-9637498-B2 | Substituted thieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2017-05-02 | — | — | US | disclosed |
| US-20170045501-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | HOWARD HUGHES MEDICAL INSTITUTE | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10018624-B1 | Azetidine-substituted fluorescent compounds | AANAT, HNMT, CHAT | CYP1A2 1366/4885GABRA5 426/4885GABRB2 295/4885 |
| US-20170045501-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | AANAT, HNMT, CHAT | CYP1A2 1366/4885GABRA5 426/4885GABRB2 295/4885 |
| US-20180172677-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | AANAT, HNMT, CHAT | CYP1A2 1366/4885GABRA5 426/4885GABRB2 295/4885 |
| US-20230159504-A1 | 7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) | SERPINA2, SERPINB1, SERPINE1 | CYP1A2 677/4885GABRA5 3466/4885GABRB2 2927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.