Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | PDE1A | P54750 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18530694 | 1.00 | HDAC1 (0.61) | HDAC1HDAC2CYP1A2PDE5APDE1A | |
| SCHEMBL3588078 | 0.83 | HDAC1 (0.66) | HDAC1HDAC2CYP1A2HDAC8HDAC6 | |
| SCHEMBL14805320 | 0.82 | CYP1A2 (0.67) | HDAC1HDAC2CYP1A2HDAC8ALDH1A1 | |
| Anthracene SCHEMBL10418182 | 0.81 | ALDH1A1 (0.54) | HDAC1HDAC2CYP1A2ALDH1A1GAA | |
| SCHEMBL140815 | 0.80 | CYP1A2 (0.65) | CYP1A2ALDH1A1MEN1KMT2AGPBAR1 | |
| SCHEMBL5503169 | 0.79 | CYP1A2 (0.63) | HDAC1HDAC2CYP1A2ALDH1A1GAA | |
| SCHEMBL4623799 | 0.79 | CYP1A2 (0.68) | HDAC1HDAC2CYP1A2ALDH1A1GAA | |
| SCHEMBL7759109 | 0.79 | CYP1A2 (0.63) | HDAC1HDAC2CYP1A2ALDH1A1GAA | |
| SCHEMBL29877127 | 0.79 | CYP1A2 (0.63) | HDAC1HDAC2CYP1A2ALDH1A1GAA | |
| SCHEMBL7831767 | 0.79 | HDAC1 (0.76) | HDAC1HDAC2HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11408893-B2 | Selective near-infrared optical imaging of necrotic cells and simultaneous cell fixing and counter staining with metallacrown complexes | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-08-09 | — | — | US | disclosed |
| US-20200064350-A1 | SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2020-02-27 | — | — | US | disclosed |
| US-10458991-B2 | Selective near-infrared optical imaging of necrotic cells and simultaneous cell fixing and counter staining with metallacrown complexes | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-29 | — | — | US | disclosed |
| EP-3335048-B1 | SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES | UNIV MICHIGAN REGENTS (US) | 2019-09-18 | — | — | EP | disclosed |
| US-10359430-B2 | — | — | 2019-07-23 | — | — | US | disclosed |
| US-20180238897-A1 | SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-08-23 | — | — | US | disclosed |
| EP-3335048-A1 | SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES | The Regents of The University of Michigan (US) | 2018-06-20 | — | — | EP | disclosed |
| WO-2017029242-A1 | SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-02-23 | — | — | WO | disclosed |
| CN-105722848-A | Metallacrown complexes and methods of making the same | 美国密西根州立大学 | 2016-06-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180238897-A1 | SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES | LITAF, CASP14, CD68 | HDAC1 519/4885HDAC2 1380/4885CYP1A2 4700/4885 |
| US-11408893-B2 | Selective near-infrared optical imaging of necrotic cells and simultaneous cell fixing and counter staining with metallacrown complexes | LITAF, CD68, CASP14 | HDAC1 290/4885HDAC2 871/4885CYP1A2 4852/4885 |
| US-10458991-B2 | Selective near-infrared optical imaging of necrotic cells and simultaneous cell fixing and counter staining with metallacrown complexes | LITAF, CASP14, CD68 | HDAC1 519/4885HDAC2 1380/4885CYP1A2 4700/4885 |
| US-10359430-B2 | — | CD44, MMP16, CDC16 | HDAC1 175/4885HDAC2 756/4885CYP1A2 3917/4885 |
| US-20200064350-A1 | SELECTIVE NEAR-INFRARED OPTICAL IMAGING OF NECROTIC CELLS AND SIMULTANEOUS CELL FIXING AND COUNTER STAINING WITH METALLACROWN COMPLEXES | LITAF, CD68, CASP14 | HDAC1 290/4885HDAC2 871/4885CYP1A2 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.