Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.66 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.53 |
| ▸ | MLYCD | O95822 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048883 | 0.88 | HDAC3 (0.60) | NAAATMEM97SIGMAR1HDAC3HDAC6 | |
| SCHEMBL5047915 | 0.88 | FOLH1 (0.55) | NAAATMEM97SIGMAR1L3MBTL1THRA | |
| SCHEMBL5044213 | 0.87 | NAAA (0.53) | NAAATMEM97SIGMAR1L3MBTL1THRA | |
| SCHEMBL5044086 | 0.87 | SPHK2 (0.57) | NAAATMEM97SIGMAR1HDAC3HDAC6 | |
| SCHEMBL1857734 | 0.84 | NAAA (0.61) | NAAATMEM97SIGMAR1L3MBTL1THRA | |
| SCHEMBL5044217 | 0.83 | KMT2A (0.49) | NAAATMEM97SIGMAR1L3MBTL1THRA | |
| SCHEMBL5044501 | 0.82 | NAAA (0.55) | NAAATMEM97SIGMAR1L3MBTL1THRA | |
| SCHEMBL1859658 | 0.81 | NAAA (0.64) | NAAATMEM97SIGMAR1L3MBTL1THRA | |
| SCHEMBL1853512 | 0.81 | NAAA (0.64) | NAAATMEM97SIGMAR1L3MBTL1THRA | |
| SCHEMBL1851125 | 0.81 | NAAA (0.64) | NAAATMEM97SIGMAR1L3MBTL1THRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-B1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | MERCK SERONO SA (CH) | 2011-05-25 | — | — | EP | claimed |