Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044086 | 0.90 | SPHK2 (0.57) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL1854693 | 0.88 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL1853317 | 0.88 | NAAA (0.66) | HDAC3HDAC1HDAC2HDAC6NAAA | |
| SCHEMBL5044217 | 0.83 | KMT2A (0.49) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL5044268 | 0.82 | NAAA (0.60) | HDAC3HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL5047915 | 0.82 | FOLH1 (0.55) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL5044213 | 0.81 | NAAA (0.53) | HDAC3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1852503 | 0.80 | SPHK2 (0.54) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL10289219 | 0.80 | HDAC3 (0.78) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL5040097 | 0.78 | NPC1 (0.68) | HDAC3HDAC1HDAC2HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |