Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045836 | 0.88 | NAAA (0.52) | NAAAL3MBTL1HDAC3SIGMAR1TMEM97 | |
| SCHEMBL1857744 | 0.86 | NAAA (0.53) | NAAAL3MBTL1HDAC3SIGMAR1TMEM97 | |
| SCHEMBL5048321 | 0.85 | NAAA (0.53) | NAAAL3MBTL1SIGMAR1TMEM97NPC1 | |
| SCHEMBL1853317 | 0.82 | NAAA (0.66) | NAAAL3MBTL1HDAC3SIGMAR1TMEM97 | |
| SCHEMBL1853858 | 0.79 | NAAA (0.52) | NAAAL3MBTL1HDAC3SIGMAR1TMEM97 | |
| SCHEMBL5040097 | 0.79 | NPC1 (0.68) | NAAAL3MBTL1HDAC3SIGMAR1THRA | |
| SCHEMBL27601082 | 0.78 | ACHE (0.61) | NAAAHDAC3HDAC1 | |
| SCHEMBL5048883 | 0.77 | HDAC3 (0.60) | NAAAHDAC3SIGMAR1TMEM97NPC1 | |
| SCHEMBL5044268 | 0.76 | NAAA (0.60) | NAAAL3MBTL1HDAC3SIGMAR1TMEM97 | |
| SCHEMBL1858193 | 0.76 | HDAC3 (0.54) | NAAAL3MBTL1HDAC3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |