Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19186103 | 0.83 | RAB9A (0.47) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A | |
| SCHEMBL20306078 | 0.82 | KMT2A (0.44) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A | |
| SCHEMBL25629349 | 0.81 | KMT2A (0.47) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A | |
| SCHEMBL27781385 | 0.79 | KMT2A (0.46) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A | |
| SCHEMBL18821943 | 0.79 | KMT2A (0.46) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A | |
| SCHEMBL20306077 | 0.78 | ALDH1A1 (0.55) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A | |
| SCHEMBL28701143 | 0.78 | MEN1 (0.57) | KMT2AMEN1RAB9ATSHR | |
| SCHEMBL26410686 | 0.78 | NOTUM (0.51) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A | |
| SCHEMBL7499151 | 0.78 | ACHE (0.59) | KMT2AMEN1PTPN1TSHR | |
| SCHEMBL27624527 | 0.77 | ACHE (0.58) | CHRNA7CHRNB2CHRNA5CHRNA4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970305-B1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2017-02-22 | — | — | EP | disclosed |