Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | SORD | Q00796 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15887424 | 0.84 | PANK3 (0.48) | PANK3RPS6KA5RPS6KA4MEN1KMT2A | |
| SCHEMBL31008978 | 0.83 | PANK3 (0.47) | PANK3RPS6KA5RPS6KA4MEN1KMT2A | |
| SCHEMBL22576020 | 0.83 | PANK3 (0.47) | PANK3RPS6KA5RPS6KA4MEN1KMT2A | |
| SCHEMBL3509457 | 0.83 | ALDH1A1 (0.47) | PANK3RPS6KA5RPS6KA4MAPTADRB1 | |
| SCHEMBL4042112 | 0.82 | HTR3A (0.53) | PANK3 | |
| SCHEMBL2088418 | 0.81 | ALDH1A1 (0.46) | PANK3RPS6KA5RPS6KA4MEN1KMT2A | |
| SCHEMBL28790483 | 0.79 | MAPT (0.66) | PANK3KMT2ALMNAMAPTSORD | |
| SCHEMBL11314201 | 0.79 | ACHE (0.50) | PANK3RPS6KA5RPS6KA4MEN1KMT2A | |
| SCHEMBL1110254 | 0.79 | PIK3CA (0.54) | PANK3MEN1KMT2AMAPTPIK3CD | |
| SCHEMBL5758330 | 0.79 | ADRB1 (0.59) | PANK3MEN1KMT2AADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805947-B1 | PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2017-02-22 | — | — | EP | disclosed |