Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18536568 | 0.76 | NPC1 (0.39) | SIGMAR1MEN1KMT2AALDH1A1GRIN2D | |
| SCHEMBL18536665 | 0.69 | ITGB1 (0.41) | SIGMAR1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL22641356 | 0.60 | RAB9A (0.50) | MAPTALDH1A1L3MBTL1ITGB3ITGB1 | |
| SCHEMBL14350992 | 0.59 | RAB9A (0.53) | SIGMAR1MAPTALDH1A1L3MBTL1ITGB3 | |
| SCHEMBL12841107 | 0.58 | PDK1 (0.56) | MAPTALDH1A1ITGB3ITGB1ITGAV | |
| SCHEMBL13433106 | 0.58 | NPC1 (0.61) | SIGMAR1MEN1KMT2AALDH1A1GRIN2D | |
| SCHEMBL11125037 | 0.57 | HPGD (0.63) | SIGMAR1MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL25006760 | 0.56 | PGR (0.47) | MEN1KMT2AMAPTALDH1A1P2RX7 | |
| SCHEMBL18594505 | 0.56 | NPC1 (0.53) | SIGMAR1ALDH1A1 | |
| SCHEMBL21164058 | 0.56 | RAB9A (0.48) | MAPTALDH1A1L3MBTL1ITGB3ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170860-B9 | BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2017-02-22 | — | — | EP | disclosed |