Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 12/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CDK11B | P21127 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30002016 | 0.88 | AXL (0.52) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL18549350 | 0.86 | ALDH1A1 (0.57) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL10086141 | 0.82 | KDM4E (0.48) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL24737265 | 0.81 | PGR (0.43) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL12923715 | 0.78 | KMT2A (0.51) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL21430571 | 0.76 | POLB (0.48) | HSD17B10KDM4EALDH1A1HPGDAXL | |
| SCHEMBL20308897 | 0.76 | MEN1 (0.47) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL18550514 | 0.76 | AXL (0.41) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL10086142 | 0.74 | ALDH1A1 (0.58) | HSD17B10KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL18548900 | 0.72 | LMNA (0.58) | HSD17B10KDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253283-A1 | PROTEIN KINASE DEGRADANT AND USE THEREOF | 中国科学院上海有机化学研究所 | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253283-A1 | PROTEIN KINASE DEGRADANT AND USE THEREOF | 中国科学院上海有机化学研究所 | 2022-12-08 | — | — | WO | disclosed |
| CN-108473434-B | Substituted quinolone derivative or pharmaceutically acceptable salt or stereoisomer thereof, and medicinal composition and application thereof | 上海海和药物研究开发股份有限公司 | 2021-11-23 | — | — | CN | disclosed |
| CN-113278010-A | Protein kinase degradation agent and application thereof | 中国科学院上海有机化学研究所 | 2021-08-20 | — | — | CN | disclosed |
| EP-3339294-B1 | QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER THEREOF AS AXL INHIBIOTOR | SHANGHAI HAIHE PHARMACEUTICAL CO LTD (CN) | 2021-04-14 | — | — | EP | disclosed |
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2020-06-16 | — | — | US | disclosed |
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2020-06-16 | — | — | US | disclosed |
| US-20180265496-A1 | SUBSTITUTED QUINOLONE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | JINAN UNIVERSITY (CN) | 2018-09-20 | — | — | US | disclosed |
| CN-108473434-A | Substituted quinolone analog derivative or its pharmaceutically acceptable salt or stereoisomer and its Pharmaceutical composition and application | 暨南大学 | 2018-08-31 | — | — | CN | disclosed |
| EP-3339294-A1 | PHARMACEUTICAL COMPOSITION AND APPLICATION REPLACING QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER | Jinan University (CN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017028797-A1 | PHARMACEUTICAL COMPOSITION AND APPLICATION REPLACING QUINOLONE DERIVATIVE, PHARMACEUTICAL ACCEPTABLE SALT, OR STEREOISOMER | 暨南大学 | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180265496-A1 | SUBSTITUTED QUINOLONE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS THEREOF, AND PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | NRAS, AXL, ABL1 | HSD17B10 3233/4885KDM4E 1861/4885ALDH1A1 3691/4885 |
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | NRAS, AXL, ABL1 | HSD17B10 3233/4885KDM4E 1861/4885ALDH1A1 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.