Sugi Predict

Sugi Predict / Compounds / SCHEMBL185559

SCHEMBL185559

SCHEMBL185559

[CH2]C(C)C(CC)c1cccc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ PNMT P11086 1/20 0.41
▸ OPRM1 P35372 3/20 0.40
▸ SLC22A1 O15245 1/20 0.40
▸ AOC3 Q16853 1/20 0.40
▸ OPRD1 P41143 2/20 0.38
▸ OPRK1 P41145 2/20 0.38
▸ OPRL1 P41146 2/20 0.38
▸ ADRB2 P07550 1/20 0.38
▸ ADRB1 P08588 1/20 0.38
▸ ADRB3 P13945 1/20 0.38
▸ SLC6A2 P23975 1/20 0.37
▸ SLC6A4 P31645 1/20 0.37
▸ SLC6A3 Q01959 1/20 0.37
▸ SLC2A1 P11166 1/20 0.37
▸ ACP3 P15309 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19850634 0.85 AOC3 (0.45) PNMTOPRM1SLC22A1AOC3OPRD1
SCHEMBL3086005 0.81 AOC3 (0.44) PNMTOPRM1AOC3OPRD1OPRK1
SCHEMBL26239181 0.77 HDAC4 (0.53) PNMTOPRM1AOC3OPRD1OPRK1
SCHEMBL199109 0.77 HDAC4 (0.53) PNMTOPRM1AOC3OPRD1OPRK1
SCHEMBL25819608 0.77 HDAC4 (0.53) PNMTOPRM1AOC3OPRD1OPRK1
SCHEMBL3397815 0.77 PNMT (0.44) PNMTOPRM1AOC3OPRD1OPRK1
SCHEMBL28063474 0.77 PNMT (0.44) PNMTOPRM1AOC3OPRD1OPRK1
SCHEMBL11130809 0.77 HKDC1 (0.50) OPRM1AOC3SLC6A2SLC6A4SLC6A3
SCHEMBL2322739 0.76 CASR (0.47) AOC3
SCHEMBL954860 0.76 AOC3 (0.42) PNMTOPRM1AOC3OPRD1OPRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1603880-B1 QUINOLINONE/BENZOXAZINONE DERIVATIVES AND USES THEREOF HOFFMANN LA ROCHE (CH) 2008-05-07 — — EP claimed
US-20240199543-A1 Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2024-06-20 — — US disclosed
US-20240158356-A1 DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS ROCHE PALO ALTO LLC (US) 2024-05-16 — — US disclosed
US-11952342-B2 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-04-09 — — US disclosed
CN-117777229-A Process for preparing an A Long Meisu ring analog 豪夫迈·罗氏有限公司 2024-03-29 — — CN disclosed
US-20240101513-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same MYDECINE INNOVATIONS GROUP INC. 2024-03-28 — — US disclosed
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same MYDECINE INNOVATIONS GROUP INC. (US) 2024-03-26 — — US disclosed
US-20240043661-A1 CYCLODEXTRIN DIMERS AND USES THEREOF UNDERDOG PHARMACEUTICALS INC (US) 2024-02-08 — — US disclosed
CN-110475766-B Process for preparing an A Long Meisu ring analog 豪夫迈·罗氏有限公司 2023-12-29 — — CN disclosed
WO-2023219789-A1 NOVEL PSILOCIN PRODRUG COMPOUNDS AND METHODS OF SYNTHESIZING THE SAME MYDECINE INNOVATIONS GROUP INC. (US) 2023-11-16 — — WO disclosed
WO-2000031033-A1 PIPERIDINE CCR-3 RECEPTOR ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2000-06-02 — — WO disclosed
WO-2000029377-A1 4-AROYL-PIPERIDIN-CCR-3 RECEPTOR ANTAGONISTS III F. HOFFMANN-LA ROCHE AG (CH) 2000-05-25 — — WO disclosed
EP-0966437-A1 5-AROYLNAPHTHALENE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 1999-12-29 — — EP disclosed
US-5998412-A ANTIARTHRITIC AGENTS; OSTEOPOROSIS SYNTEX (U.S.A.) INC. (US) 1999-12-07 — — US disclosed
EP-0958287-A1 SULFAMIDE-METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 1999-11-24 — — EP disclosed
US-5962531-A PROSTAGLANDIN SYNTHASE INHIBITOR; RHEUMATIC DISORDERS SYNTEX (U.S.A.) INC. (US) 1999-10-05 — — US disclosed
WO-1999020624-A1 BICYCLIC KINASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 1999-04-29 — — WO disclosed
EP-0903349-A2 CCR-3 receptor antagonists F. HOFFMANN-LA ROCHE AG (CH) 1999-03-24 — — EP disclosed
WO-1998032748-A1 SULFAMIDE-METALLOPROTEASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 1998-07-30 — — WO disclosed
WO-1998032732-A1 5-AROYLNAPHTHALENE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1998-07-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240101513-A1 Novel Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same TOP2A, PAICS, TOP1 PNMT 21/4885OPRM1 3015/4885SLC22A1 1640/4885
US-11952342-B2 Aza-substituted psilocin analogs and methods of synthesizing the same TOP2A, PAICS, TOP1 PNMT 12/4885OPRM1 2574/4885SLC22A1 1894/4885
US-20240158356-A1 DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS P2RX3, P2RX6, P2RX2 PNMT 3600/4885OPRM1 270/4885SLC22A1 789/4885
US-20240199543-A1 Aza-Substituted Psilocin Analogs And Methods Of Synthesizing The Same TOP2A, PAICS, TOP1 PNMT 12/4885OPRM1 2574/4885SLC22A1 1894/4885
US-11939292-B1 Aza-substituted psilocin analogs and methods of synthesizing the same TOP2A, PAICS, TOP1 PNMT 12/4885OPRM1 2574/4885SLC22A1 1894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.