Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186038 | 0.88 | NAMPT (0.40) | LMNAHDAC1PTK2 | |
| SCHEMBL2806663 | 0.86 | LMNA (0.40) | LMNAMAPK1CRACR2AP2RX7HDAC1 | |
| SCHEMBL13128459 | 0.86 | LMNA (0.40) | LMNAMAPK1CRACR2AP2RX7HDAC1 | |
| SCHEMBL185629 | 0.82 | POLB (0.36) | LMNAMAPK1P2RX7ALDH1A1POLB | |
| SCHEMBL185869 | 0.81 | ALDH1A1 (0.35) | LMNAALDH1A1POLBPTK2RAB9A | |
| SCHEMBL185812 | 0.80 | POLB (0.34) | POLBHTR1ADRD2EPHX2PTK2 | |
| SCHEMBL186396 | 0.80 | HPGD (0.40) | LMNAP2RX7POLBSMN1; SMN2 | |
| SCHEMBL186112 | 0.80 | HDAC1 (0.39) | ALDH1A1POLBHDAC1PTK2RAB9A | |
| SCHEMBL185726 | 0.80 | GAA (0.42) | LMNAALDH1A1POLBHDAC1EPHX2 | |
| SCHEMBL185723 | 0.79 | KCNH2 (0.41) | ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |