Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1861814 | 0.82 | EPHX1 (0.47) | TRPM8SMN1; SMN2EPHX1ALDH1A1HPGD | |
| SCHEMBL29533375 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL31486820 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL29007016 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL529952 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL23062653 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL1159800 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL31658232 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL4132345 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL2628659 | 0.81 | TRPM8 (0.52) | TRPM8SMN1; SMN2CYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155151-B1 | Butanone derivatives and use thereof as cooling agents | GIVAUDAN SA (CH) | 2013-07-31 | — | — | EP | claimed |
| US-7935848-B2 | Butone derivatives useful as cooling agents | GIVAUDAN S.A. (CH) | 2011-05-03 | — | — | US | claimed |
| US-20100197713-A1 | BUTONE DERIVATIVES USEFUL AS COOLING AGENTS | GIVAUDAN SA (CH) | 2010-08-05 | — | — | US | claimed |
| EP-2155151-A2 | ORGANIC COMPOUNDS | Givaudan SA (CH) | 2010-02-24 | — | — | EP | claimed |
| WO-2008141469-A2 | BUTONE DERIVATIVES USEFUL AS COOLING AGENTS | GIVAUDAN SA (CH) | 2008-11-27 | — | — | WO | claimed |
| EP-2155151-B1 | Butanone derivatives and use thereof as cooling agents | GIVAUDAN SA (CH) | 2013-07-31 | — | — | EP | disclosed |
| US-7935848-B2 | Butone derivatives useful as cooling agents | GIVAUDAN S.A. (CH) | 2011-05-03 | — | — | US | disclosed |
| US-20100197713-A1 | BUTONE DERIVATIVES USEFUL AS COOLING AGENTS | GIVAUDAN SA (CH) | 2010-08-05 | — | — | US | disclosed |
| EP-2155151-A2 | ORGANIC COMPOUNDS | Givaudan SA (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141469-A2 | BUTONE DERIVATIVES USEFUL AS COOLING AGENTS | GIVAUDAN SA (CH) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197713-A1 | BUTONE DERIVATIVES USEFUL AS COOLING AGENTS | C1S, HSD3B1, DECR1 | TRPM8 3493/4885SMN1; SMN2 3771/4885CYP1A2 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.