Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15342927 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL29533375 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL31486820 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL2628659 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL31658232 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL23062653 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL4132345 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL1159800 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL29007016 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 | |
| SCHEMBL10044144 | 1.00 | TRPM8 (0.52) | TRPM8ALOX5APHSD11B1SMN1; SMN2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122028893-A | Composition and method for producing the same | 奇华顿股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-117956976-A | Nonaqueous oral composition | 狮王株式会社 | 2024-04-30 | — | — | CN | claimed |
| US-20240058259-A1 | COMPOSITIONS COMPRISING ESSENTIAL OILS | FIRMENICH SA (CH) | 2024-02-22 | — | — | US | claimed |
| EP-4192422-A1 | COOLING SENSATION COMPOSITIONS | Givaudan SA (CH) | 2023-06-14 | — | — | EP | claimed |
| CN-116018128-A | Cooling composition | 奇华顿股份有限公司 | 2023-04-25 | — | — | CN | claimed |
| EP-2906196-B1 | COSMETIC OR DERMATOLOGICAL PREPARATION FOR PROPHYLAXIS AND/OR TREATMENT OF ATOPIC DERMATITIS | BEIERSDORF AG (DE) | 2022-08-31 | — | — | EP | claimed |
| EP-3996505-A1 | SYNERGISTIC FORMULATIONS FOR CONTROL AND REPELLENCY OF BITING ARTHROPODS | Bedoukian Research, Inc. (US) | 2022-05-18 | — | — | EP | claimed |
| EP-3996506-A1 | FORMULATIONS FOR CONTROL AND REPELLENCY OF BITING ARTHROPODS | Bedoukian Research, Inc. (US) | 2022-05-18 | — | — | EP | claimed |
| WO-2022028726-A1 | COOLING SENSATION COMPOSITIONS | GIVAUDAN SA (CH) | 2022-02-10 | — | — | WO | claimed |
| US-11059783-B2 | Pyridinyl cyclohexanecarboxamide cooling compounds | GIVAUDAN S.A. (CH) | 2021-07-13 | — | — | US | claimed |
| EP-2168957-B1 | Alkyl-substituted tetrahydropyranes as aromatic materials | SYMRISE AG (DE) | 2012-02-15 | — | — | EP | claimed |
| WO-2012013515-A2 | SKIN PATCH HAVING OPTIMIZED ACTIVE SUBSTANCE RELEASE | BEIERSDORF AG (DE) | 2012-02-02 | — | — | WO | claimed |
| US-20110091531-A1 | Cooling Composition | GIV AUDAN SA (CH) | 2011-04-21 | — | — | US | claimed |
| US-20100226864-A1 | ALKYL-SUBSTITUTED TETRAHYDROPYRANS AS FLAVORING SUBSTANCES | SYMRISE GMBH & CO. KG (DE) | 2010-09-09 | — | — | US | claimed |
| EP-2168957-A2 | Alkyl-substituted tetrahydropyranes as aromatic materials | Symrise GmbH & Co. KG (DE) | 2010-03-31 | — | — | EP | claimed |
| US-20100035938-A1 | Cooling Compounds | GIVAUDAN SA (CH) | 2010-02-11 | — | — | US | claimed |
| US-20090311206-A1 | COOLING COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYL)-CYCLOHEXANE CARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-CYANOMETHYL-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE FOR REDUCING SKIN REDDENING | BEIERSDORF AG (DE) | 2009-12-17 | — | — | US | claimed |
| US-20090306152-A1 | COOLING COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYL)-CYCLOHEXANE CARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-CYANOMETHYL-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE IN COMBINATION WITH MENTHOXYPROPANEDIOL | BEIERSDORF AG. (DE) | 2009-12-10 | — | — | US | claimed |
| US-20080311266-A1 | Salt Enhancement | GRAY KIMBERLEY H | 2008-12-18 | — | — | US | claimed |
| WO-2008138162-A1 | COMPOSITIONS AND THEIR USE | GIVAUDAN SA (CH) | 2008-11-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059783-B2 | Pyridinyl cyclohexanecarboxamide cooling compounds | CBR3, TAS2R31, CTRB2 | TRPM8 199/4885ALOX5AP 417/4885HSD11B1 3089/4885 |
| US-20100226864-A1 | ALKYL-SUBSTITUTED TETRAHYDROPYRANS AS FLAVORING SUBSTANCES | TAS1R3, TAS2R10, TAS2R50 | TRPM8 131/4885ALOX5AP 843/4885HSD11B1 3113/4885 |
| US-20090306152-A1 | COOLING COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYL)-CYCLOHEXANE CARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-CYANOMETHYL-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE IN COMBINATION WITH MENTHOXYPROPANEDIOL | CUTA, ACMSD, DECR2 | TRPM8 41/4885ALOX5AP 574/4885HSD11B1 1070/4885 |
| US-20090311206-A1 | COOLING COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYL)-CYCLOHEXANE CARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-CYANOMETHYL-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE FOR REDUCING SKIN REDDENING | CUTA, MC5R, MC1R | TRPM8 138/4885ALOX5AP 1446/4885HSD11B1 2515/4885 |
| US-20100035938-A1 | Cooling Compounds | EBP, HRH1, TAS2R42 | TRPM8 742/4885ALOX5AP 1142/4885HSD11B1 900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.