Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.51 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19524164 | 0.90 | MAPT (0.65) | MAPTL3MBTL1LMNAATMSCN8A | |
| SCHEMBL19524139 | 0.84 | SCN8A (0.52) | L3MBTL1SCN8ASCN10ACYP1A1CYP1B1 | |
| SCHEMBL18570917 | 0.83 | SCN8A (0.51) | MAPTLMNASCN8ASCN10AERN1 | |
| SCHEMBL22809589 | 0.82 | SLC6A4 (0.56) | MAPTL3MBTL1LMNAATMSCN8A | |
| SCHEMBL18570517 | 0.82 | L3MBTL1 (0.62) | MAPTL3MBTL1LMNAATMSCN8A | |
| SCHEMBL18570579 | 0.81 | L3MBTL1 (0.46) | MAPTL3MBTL1LMNAATMSCN8A | |
| SCHEMBL19563647 | 0.80 | SCN8A (0.46) | MAPTL3MBTL1LMNAATMSCN8A | |
| SCHEMBL19563652 | 0.80 | HTR2A (0.51) | MAPTL3MBTL1LMNAATMSCN8A | |
| SCHEMBL7138558 | 0.79 | LMNA (0.57) | MAPTL3MBTL1LMNAATMSCN8A | |
| SCHEMBL22809585 | 0.79 | SCN8A (0.48) | MAPTL3MBTL1LMNAATMSCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-A1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |