Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22932078 | 0.87 | ALDH1A1 (0.50) | ALDH1A1TSHRKMT2AMEN1RXRA | |
| SCHEMBL24675644 | 0.86 | PLA2G4B (0.48) | ALDH1A1TSHRKMT2AMEN1TDP1 | |
| SCHEMBL25823398 | 0.86 | PLA2G4B (0.48) | ALDH1A1TSHRKMT2AMEN1TDP1 | |
| SCHEMBL24675646 | 0.86 | PLA2G4B (0.48) | ALDH1A1TSHRKMT2AMEN1TDP1 | |
| SCHEMBL25823855 | 0.84 | PLA2G4B (0.46) | ALDH1A1TSHRTDP1POLBL3MBTL1 | |
| SCHEMBL801233 | 0.82 | ALDH1A1 (0.72) | ALDH1A1TSHRKMT2ARXRARXRB | |
| SCHEMBL18591858 | 0.82 | KMT2A (0.43) | ALDH1A1KMT2AMEN1RXRARXRB | |
| SCHEMBL24935185 | 0.82 | KMT2A (0.50) | KMT2AMEN1RXRARXRBTDP1 | |
| SCHEMBL15942954 | 0.81 | MEN1 (0.55) | ALDH1A1TSHRKMT2AMEN1RXRA | |
| SCHEMBL14579974 | 0.80 | MEN1 (0.62) | KMT2AMEN1RXRARXRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230263893-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | ARVINAS OPERATIONS, INC. | 2023-08-24 | — | — | US | disclosed |
| US-20170065719-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | ARVINAS OPERATIONS, INC. | 2017-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230263893-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | BRPF3, STUB1, BRDT | ALDH1A1 3365/4885TSHR 3658/4885KMT2A 755/4885 |
| US-20170065719-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | BRPF3, STUB1, BRDT | ALDH1A1 3365/4885TSHR 3658/4885KMT2A 755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.