SCHEMBL185991

SCHEMBL185991

O=C(O)c1ccc(O)nc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P4HA1 P13674 3/20 0.64
P4HTM Q9NXG6 2/20 0.64
MIF P14174 1/20 0.61
GABRP O00591 1/20 0.59
GABRD O14764 1/20 0.59
GABRA1 P14867 1/20 0.59
GABRB1 P18505 1/20 0.59
GABRG2 P18507 1/20 0.59
GABRB3 P28472 1/20 0.59
GABRA5 P31644 1/20 0.59
GABRA3 P34903 1/20 0.59
GABRA2 P47869 1/20 0.59
GABRB2 P47870 1/20 0.59
GABRA4 P48169 1/20 0.59
GABRE P78334 1/20 0.59
GABRA6 Q16445 1/20 0.59
GABRG1 Q8N1C3 1/20 0.59
GABRG3 Q99928 1/20 0.59
GABRQ Q9UN88 1/20 0.59
NAPRT Q6XQN6 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29524968 1.00 P4HA1 (0.64) P4HA1P4HTMMIFGABRPGABRD
Hydrochloric Acid SCHEMBL9162215 0.98 P4HA1 (0.61) P4HA1P4HTMMIFGABRPGABRD
SCHEMBL31350195 0.85 P4HA1 (0.47) P4HA1P4HTMMIFGABRPGABRD
SCHEMBL4037565 0.82 P4HA1 (0.46) P4HA1P4HTMMIFGABRPGABRD
SCHEMBL24400225 0.79 NAPRT (0.42) P4HA1P4HTMMIFGABRPGABRD
SCHEMBL447959 0.79 NNMT (0.63) TSHR
SCHEMBL1092282 0.79 KCNJ1 (0.47) P4HA1P4HTMMIFGABRPGABRD
SCHEMBL2255291 0.79 NAPRT (0.47) P4HA1P4HTMMIFGABRPGABRD
SCHEMBL31196295 0.79 NNMT (0.63) TSHR
SCHEMBL11285208 0.79 CES2 (0.60) P4HA1P4HTMALDH1A1HCAR3LDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2017 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
WO-2026098617-A1 RADIOPHARMACEUTICAL TARGETING CARBONIC ANHYDRASE IX PROTEIN 无锡诺宇医药科技有限公司 2026-05-15 WO claimed
CN-121550254-B Pharmaceutical composition for improving pancreatic cancer treatment effect 浙江省肿瘤医院 2026-05-15 CN claimed
WO-2025202864-A1 ENT1 INHIBITORS IN COMBINATION WITH ONCOLYTIC VIRUSES AND THEIR USE IN THE TREATMENT OF CANCER iTeos Belgium SA (BE) 2025-10-02 WO claimed
US-20250297057-A1 LIQUID CRYSTALLINE POLYESTER, MOLDED ARTICLE, AND ELECTRIC/ELECTRONIC COMPONENT ENEOS MATERIALS CORPORATION (JP) 2025-09-25 US claimed
WO-2025126110-A1 ENT1 INHIBITORS IN COMBINATION WITH BISPECIFIC ANTIBODIES iTeos Belgium SA (BE) 2025-06-19 WO claimed
CN-120052357-A Application of 6-hydroxynicotinic acid in preventing and controlling orobanche and improving aboveground biomass of plants 石河子大学 2025-05-30 CN claimed
WO-2025104613-A1 ENT1 INHIBITORS IN COMBINATION WITH CHECKPOINT INHIBITORS iTeos Belgium SA (BE) 2025-05-22 WO claimed
CN-119699546-A Flavor composition and method of making food products of the flavor composition 北京市农林科学院 2025-03-28 CN claimed
WO-2025019764-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS MATTERWORKS INC (US) 2025-01-23 WO claimed
US-5151351-A Culture of nicotinic acid with Achromobacter and Pseudomonas to form a hydroxy group LONZA LTD. (CH) 1992-09-29 US claimed
US-5082777-A Biosynthesis LONZA LTD. (CH) 1992-01-21 US claimed
EP-0152948-B1 PROCESS FOR THE PREPARATION OF 6-HYDROXYNICOTINIC ACID LONZA AG (CH) 1991-05-08 EP claimed
EP-0422765-A1 Cosmetic composition UNILEVER PLC (GB) 1991-04-17 EP claimed
EP-0206293-B1 PROCESS FOR THE PREPARATION OF 3,5-DICHLORO-2-PYRIDONE LONZA AG (CH) 1991-03-20 EP claimed
US-4738924-A Method for the production of 6-hydroxynicotinic acid LONZA LTD. (CH) 1988-04-19 US claimed
US-4681942-A Process for the production of 3,5-dichloro-2-pyridone LONZA LTD. (CH) 1987-07-21 US claimed
US-4394444-A PYRIDINE NUCLEOTIDE, PEROXIDASE MILES LABORATORIES, INC. (US) 1983-07-19 US claimed
US-4230864-A Process for making 5-trifluoromethyl pyridone REILLY TAR & CHEMICAL CORP. (US) 1980-10-28 US claimed
US-4141977-A Treatment of psoriasis with 6-substituted nicotinamides, 2-substituted pyrazinamides and closely related compounds YU RUEY J 1979-02-27 US claimed