Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 3/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 3/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 3/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21143494 | 0.82 | HDAC1 (0.50) | HDAC1HDAC6PDPK1PLAAT3PLAAT5 | |
| SCHEMBL22522171 | 0.81 | HDAC1 (0.49) | HDAC1HDAC6PDPK1PLAAT3PLAAT5 | |
| SCHEMBL24264804 | 0.80 | GPR52 (0.59) | HDAC1HDAC6FFAR1HDAC3HDAC4 | |
| SCHEMBL5844891 | 0.78 | PLAAT3 (0.51) | HDAC1HDAC6PDPK1PLAAT3PLAAT5 | |
| SCHEMBL7328721 | 0.77 | PLAAT3 (0.55) | HDAC1HDAC6PDPK1PLAAT3PLAAT5 | |
| SCHEMBL1154480 | 0.75 | PLAAT3 (0.53) | HDAC1HDAC6PDPK1PLAAT3PLAAT5 | |
| SCHEMBL349314 | 0.75 | FFAR1 (0.71) | PDPK1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL19288070 | 0.75 | TSHR (0.56) | MEN1KMT2ACNR1 | |
| SCHEMBL1776 | 0.74 | ALDH1A1 (0.63) | HDAC1HDAC6PDPK1PLAAT3PLAAT5 | |
| SCHEMBL9404040 | 0.74 | F2RL1 (0.58) | HDAC1HDAC6PDPK1PLAAT3PLAAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344616-B1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS | ONCOARENDI THERAPEUTICS SA (PL) | 2019-01-09 | — | — | EP | disclosed |
| WO-2017037670-A1 | SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS | OncoArendi Therapeutics Sp. z o.o. (PL) | 2017-03-09 | — | — | WO | disclosed |