Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22820555 | 0.84 | PTGS2 (0.51) | KMT2ALMNAMEN1MMP8ACHE | |
| SCHEMBL27595607 | 0.84 | MAPT (0.47) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL28224535 | 0.84 | ESR1 (0.52) | MAPTKMT2ALMNACYP1A2ALDH1A1 | |
| SCHEMBL20930834 | 0.83 | KMT2A (0.50) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL31482742 | 0.83 | KMT2A (0.44) | MAPTKMT2ALMNANPSR1MEN1 | |
| SCHEMBL11260308 | 0.82 | LMNA (0.53) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL2799224 | 0.82 | CA12 (0.50) | MAPTLMNANPSR1HTTCYP1A2 | |
| SCHEMBL7987182 | 0.82 | OPRM1 (0.38) | KMT2ALMNAMEN1MAPK1MMP8 | |
| SCHEMBL20943223 | 0.81 | CYP1A2 (0.48) | KMT2ACYP1A2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL11598177 | 0.81 | LMNA (0.49) | MAPTKMT2ALMNANPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017037595-A1 | NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-03-09 | — | — | WO | disclosed |
| CN-103724296-B | Piperazine carbonyl derivative that aryl replaces and its preparation method and application | NANJING MEDICAL UNIVERSITY (CN) | 2015-09-02 | — | — | CN | disclosed |
| CN-103724296-A | Aryl substituted piperazine carbonyl derivative as well as preparation method and application thereof | UNIV NANJING MEDICAL | 2014-04-16 | — | — | CN | disclosed |
| CN-1097051-C | N-heteroaryl-pyridinesulfonamide derivatives and their use as endothelin antagonists | ZENECA LTD (GB) | 2002-12-25 | — | — | CN | disclosed |
| CN-1192739-A | N-heteroaryl-pyridinesulfonamide derivatives and their use as endothelin antagonists | ZENECA LTD (GB) | 1998-09-09 | — | — | CN | disclosed |