Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 3/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9852820 | 0.85 | KMT2A (0.40) | KMT2ALMNAMAPTNPSR1CCNC | |
| SCHEMBL7020112 | 0.81 | ALDH1A1 (0.33) | GLAP4HTM | |
| SCHEMBL185429 | 0.80 | ALDH1A1 (0.40) | KMT2ALMNANPSR1GLANPC1 | |
| SCHEMBL186657 | 0.78 | KMT2A (0.34) | KMT2ALMNAMAPTNPSR1CCNC | |
| SCHEMBL3819124 | 0.77 | NQO1 (0.50) | KMT2AMAPTPARP10NPC1 | |
| SCHEMBL186124 | 0.76 | MAPT (0.59) | MAPTPLA2G4BCYP2C9CYP2C19P4HTM | |
| SCHEMBL185620 | 0.75 | LMNA (0.35) | KMT2ALMNAMAPTCYP2C9CYP2C19 | |
| SCHEMBL186360 | 0.74 | VNN1 (0.40) | KMT2AACACBCYP2C19L3MBTL1GLA | |
| SCHEMBL7166940 | 0.74 | NQO1 (0.61) | KMT2ALMNANPSR1PARP10PLA2G4B | |
| SCHEMBL185449 | 0.73 | ALDH1A1 (0.33) | GLAP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |