Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 3/20 | 0.68 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.68 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.68 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.68 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.56 |
| ▸ | MERTK | Q12866 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CCNC | P24863 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615511 | 0.90 | BMPR1B (0.62) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18617156 | 0.87 | PIK3C3 (0.59) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18617157 | 0.87 | FYN (0.66) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18616326 | 0.86 | BMPR1B (0.57) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL24319038 | 0.85 | KCNH2 (0.67) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18616316 | 0.83 | MERTK (0.57) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18616286 | 0.83 | MERTK (0.55) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL19807056 | 0.81 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL29370385 | 0.81 | BMPR1B (1.00) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18612197 | 0.81 | MERTK (0.59) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |