Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 4/20 | 0.57 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.57 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.57 |
| ▸ | MERTK | Q12866 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | CCNC | P24863 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18615504 | 0.86 | BMPR1B (0.68) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18612197 | 0.86 | MERTK (0.59) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18615511 | 0.85 | BMPR1B (0.62) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18616701 | 0.79 | BMPR1B (0.71) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18617182 | 0.77 | CHEK2 (0.64) | BMPR1BBMPR1AACVRL1ACVR1TGFBR1 | |
| SCHEMBL18611892 | 0.76 | MERTK (0.55) | MERTKAXLPIK3CB | |
| SCHEMBL30108250 | 0.76 | HPGD (0.53) | HRH3CA12CA1CA2CA7 | |
| SCHEMBL28225055 | 0.76 | HPGD (0.53) | HRH3CA12CA1CA2CA7 | |
| SCHEMBL18612199 | 0.75 | L3MBTL3 (0.59) | MERTKAXL | |
| SCHEMBL18615821 | 0.75 | MERTK (0.58) | MERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947215-B2 | Heteroaryl compounds and their use as therapeutic drugs | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2021-03-16 | — | — | US | disclosed |
| EP-3344613-B1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG A SOCIO HOLDINGS CO LTD (KR) | 2020-03-04 | — | — | EP | disclosed |
| US-20190119252-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2019-04-25 | — | — | US | disclosed |
| WO-2017039331-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | DONG-A SOCIO HOLDINGS CO., LTD. (KR) | 2017-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947215-B2 | Heteroaryl compounds and their use as therapeutic drugs | MERTK, ERBB2, SRC | BMPR1B 2861/4885BMPR1A 2844/4885ACVRL1 2320/4885 |
| US-20190119252-A1 | HETEROARYL COMPOUNDS AND THEIR USE AS THERAPEUTIC DRUGS | MERTK, ERBB2, SRC | BMPR1B 2861/4885BMPR1A 2844/4885ACVRL1 2320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.