Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 4/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186360 | 0.86 | VNN1 (0.40) | HCAR3ACACBVNN1ALDH1A1HPGD | |
| SCHEMBL16824294 | 0.84 | HCAR3 (0.48) | HCAR3HDAC3HDAC1HDAC2ACACB | |
| SCHEMBL186222 | 0.77 | HCAR3 (0.63) | HCAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL186008 | 0.77 | GRM5 (0.39) | HCAR3HDAC3HDAC1HDAC2ACACB | |
| SCHEMBL17676668 | 0.75 | HCAR3 (0.47) | HCAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL10589105 | 0.74 | CYP1A2 (0.41) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL186657 | 0.73 | KMT2A (0.34) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL200701 | 0.72 | HDAC3 (0.41) | HCAR3HDAC3HDAC1HDAC2ACACB | |
| SCHEMBL186125 | 0.72 | KMT2A (0.40) | ACACB | |
| SCHEMBL185620 | 0.70 | LMNA (0.35) | KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |