Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1862411 | 0.95 | ALDH1A1 (0.40) | LMNAALDH1A1P2RX7OPRM1OPRL1 | |
| SCHEMBL1866642 | 0.95 | ALDH1A1 (0.40) | LMNAALDH1A1P2RX7OPRM1OPRL1 | |
| SCHEMBL1865507 | 0.90 | ALDH1A1 (0.42) | LMNAALDH1A1OPRM1OPRL1MEN1 | |
| SCHEMBL9639574 | 0.86 | DPP4 (0.41) | LMNAOPRM1NPSR1OPRD1 | |
| SCHEMBL1863575 | 0.79 | CHRNB2 (0.37) | LMNAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL5760516 | 0.77 | SLC6A3 (0.39) | S1PR1 | |
| SCHEMBL1866073 | 0.75 | HTR2A (0.38) | LMNAALDH1A1OPRM1OPRL1MEN1 | |
| SCHEMBL1865938 | 0.75 | HTR2A (0.38) | LMNAALDH1A1OPRM1OPRL1MEN1 | |
| SCHEMBL1860147 | 0.75 | HTR2A (0.38) | LMNAALDH1A1OPRM1OPRL1MEN1 | |
| SCHEMBL23722370 | 0.68 | ALDH1A1 (0.55) | LMNAALDH1A1OPRM1OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493877-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053705-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |