Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866642 | 0.91 | ALDH1A1 (0.40) | ALDH1A1LMNAOPRM1OPRL1MEN1 | |
| SCHEMBL1862411 | 0.91 | ALDH1A1 (0.40) | ALDH1A1LMNAOPRM1OPRL1MEN1 | |
| SCHEMBL1862897 | 0.90 | LMNA (0.39) | ALDH1A1LMNAOPRM1OPRL1MEN1 | |
| SCHEMBL1860147 | 0.80 | HTR2A (0.38) | ALDH1A1LMNAOPRM1OPRL1MEN1 | |
| SCHEMBL1866073 | 0.80 | HTR2A (0.38) | ALDH1A1LMNAOPRM1OPRL1MEN1 | |
| SCHEMBL1865938 | 0.80 | HTR2A (0.38) | ALDH1A1LMNAOPRM1OPRL1MEN1 | |
| SCHEMBL1863575 | 0.78 | CHRNB2 (0.37) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL159063 | 0.76 | HCAR2 (0.38) | ALDH1A1LMNAOPRM1OPRL1MEN1 | |
| SCHEMBL9639574 | 0.72 | DPP4 (0.41) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL27426615 | 0.70 | ALDH1A1 (0.40) | ALDH1A1LMNAOPRM1OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493877-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053705-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |