Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | TK1 | P04183 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12617990 | 1.00 | RAPGEF4 (0.32) | RAPGEF4TK1ADRB1DNMT1POLB | |
| SCHEMBL1795916 | 0.82 | ATG7 (0.44) | — | |
| SCHEMBL1799615 | 0.77 | ADRB1 (0.46) | TK1ADRB1DNMT1 | |
| SCHEMBL23982318 | 0.77 | ADRB1 (0.46) | TK1ADRB1DNMT1 | |
| SCHEMBL1795979 | 0.69 | POLB (0.36) | ADRB1DNMT1POLB | |
| SCHEMBL1795315 | 0.67 | ATG7 (0.52) | — | |
| SCHEMBL20419147 | 0.63 | LMNA (0.54) | DNMT1 | |
| SCHEMBL26707698 | 0.62 | AOC3 (0.41) | RAPGEF4CDC7CDK2 | |
| SCHEMBL1799305 | 0.62 | ATG7 (0.45) | — | |
| SCHEMBL1797175 | 0.62 | UPP1 (0.43) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170073367-A9 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENIUM PHARMACEUTICALS, INC. | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073367-A9 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | RAPGEF4 2336/4885TK1 24/4885ADRB1 3455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.