SCHEMBL186305

SCHEMBL186305

NC(=O)c1ccc(CCl)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 4/20 0.61
CA1 P00915 3/20 0.61
PLA2G10 O15496 1/20 0.57
PLA2G2A P14555 1/20 0.57
PARP10 Q53GL7 8/20 0.53
CYP17A1 P05093 1/20 0.48
PARP4 Q9UKK3 2/20 0.48
KMT2A Q03164 2/20 0.48
ALDH1A1 P00352 1/20 0.48
PARP15 Q460N3 1/20 0.48
PARP14 Q460N5 1/20 0.48
PARP16 Q8N5Y8 1/20 0.48
PARP11 Q9NR21 1/20 0.48
PARP1 P09874 3/20 0.48
TSHR P16473 2/20 0.48
POLB P06746 1/20 0.48
CYP3A4 P08684 1/20 0.48
MAPT P10636 1/20 0.48
CYP2C19 P33261 1/20 0.48
RECQL P46063 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenol SCHEMBL7153494 0.87 PLA2G10 (0.59) CA2CA1PLA2G10PLA2G2APARP10
Benzamide SCHEMBL5499602 0.87 PLA2G10 (0.59) CA2CA1PLA2G10PLA2G2APARP10
SCHEMBL5648580 0.82 PLA2G10 (0.53) CA2CA1PLA2G10PLA2G2APARP10
SCHEMBL1559089 0.80 CA1 (0.67) CA2CA1KMT2AALDH1A1MAPT
SCHEMBL7134591 0.80 PLA2G10 (0.83) CA2CA1PLA2G10PLA2G2APARP10
Terephthalamide SCHEMBL23774 0.79 PARP1 (0.71) CA2CA1PLA2G10PLA2G2APARP10
SCHEMBL2642291 0.78 PLA2G10 (0.59) CA2CA1PLA2G10PLA2G2APARP10
SCHEMBL13683319 0.78 CA1 (0.64) CA2CA1KMT2AALDH1A1TSHR
Terephthalamide SCHEMBL3444098 0.78 LOXL2 (0.60) CA2PLA2G10PLA2G2APARP10CYP17A1
SCHEMBL1596773 0.78 CA1 (0.64) CA2CA1KMT2AALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116891472-A Amide derivative containing imidazole structure, and preparation method and application thereof 延边大学 2023-10-17 CN claimed
CN-110559299-A composition containing pyridyl pyrimidinamine compound and application thereof 黄泳华 2019-12-13 CN claimed
US-8519040-B2 Ionic organic compound, production method thereof, hydrogelling agent composed of the ionic organic compound, hydrogel containing same, methanol gelling agent, methanol gel containing same, and carbon nanotube dispersant NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2013-08-27 US claimed
US-20110178218-A1 IONIC ORGANIC COMPOUND, PRODUCTION METHOD THEREOF, HYDROGELLING AGENT COMPOSED OF THE IONIC ORGANIC COMPOUND, HYDROGEL CONTAINING SAME, METHANOL GELLING AGENT, METHANOL GEL CONTAINING SAME, AND CARBON NANOTUBE DISPERSANT National Institute of Avanced Industrial Science and Technology (JP) 2011-07-21 US claimed
EP-2330143-A1 IONIC ORGANIC COMPOUND, PRODUCTION METHOD THEREOF, HYDROGELLING AGENT COMPOSED OF THE IONIC ORGANIC COMPOUND, HYDROGEL CONTAINING SAME, METHANOL GELLING AGENT, METHANOL GEL CONTAINING SAME, AND CARBON NANOTUBE DISPERSANT National Institute of Advanced Industrial Science And Technology (JP) 2011-06-08 EP claimed
CN-1121137-C Fungicidal compositions containing N-acetonylbenzamides DAW AGRICULTURAL CO LTD (US) 2003-09-17 CN claimed
EP-1150565-A1 THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION bioscience AG (DE) 2001-11-07 EP claimed
WO-2000045635-A1 THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2000-08-10 WO claimed
EP-0116942-B1 METHOD TO PREPARE 4,4'-BIS-BENZ-OX(THI, -IMID)-AZOL-2-YL STILBENES HOECHST AKTIENGESELLSCHAFT (DE) 1986-07-16 EP claimed
CN-120629407-A Method for detecting related substances in imacid dihydrochloride by HPLC (high Performance liquid chromatography) 远大武药(江苏)制药有限公司 2025-09-12 CN disclosed
US-20250170117-A1 MODULATORS OF ACKR3 AND USES THEREOF INTERAX BIOTECH AG (CH) 2025-05-29 US disclosed
EP-4486739-A1 MODULATORS OF ACKR3 AND USES THEREOF InterAx Biotech AG (CH) 2025-01-08 EP disclosed
US-20240308989-A1 PYRAN DERIVATIVES AS CYP11A1 (CYTOCHROME P450 MONOOXYGENASE 11A1) INHIBITORS ORION CORP (FI) 2024-09-19 US disclosed
CN-118638077-A Amide/sulfonamide CXCR4/HDAC dual inhibitor and preparation method and application thereof 杭州师范大学 2024-09-13 CN disclosed
WO-1995034595-A1 ANTIVIRAL DENDRIMERS BIOMOLECULAR RESEARCH INSTITUTE LTD. (AU) 1995-12-21 WO disclosed
CN-1089595-A N-acetonyl benzamide and fungicidal action thereof ROHM & HAAS (US) 1994-07-20 CN disclosed
US-4665073-A HISTAMINE H2-ANTAGONISTS ICI AMERICAS INC. (GB) 1987-05-12 US disclosed
EP-0060094-B1 GUANIDINE DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-01-22 EP disclosed
US-4447441-A ANTIHISTAMINE, ANTIULCER AND ANTISECRETORY AGENT IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-05-08 US disclosed
EP-0060094-A2 Guanidine derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-09-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250170117-A1 MODULATORS OF ACKR3 AND USES THEREOF ACKR3, PROKR2, PROKR1 CA2 2281/4885CA1 3356/4885PLA2G10 3223/4885
US-20240308989-A1 PYRAN DERIVATIVES AS CYP11A1 (CYTOCHROME P450 MONOOXYGENASE 11A1) INHIBITORS CYP11B1, CYP11B2, CYP4A11 CA2 2874/4885CA1 2748/4885PLA2G10 1460/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.